We use activity based probes and proteomics to identify ubiquitin and ubiquitin-like enzymes across different developmental stages. We use biochemical and structural biology approaches to characterise activity and specificity.
We use parasite transgenics to disrupt and tag novel enzymes. Identifying new proteins and functionally characterising them. We aim to understand how these enzymes are used by the parasites and how ubiquitin and other post-translational modifiers regulate pathways critical to development and survival of these pathogens.
Many of the pathways and enzymes we study are essential for parasite survival. We use a variety of methods to develop inhibitors including biophysical approaches, small molecule screens and peptide discovery. We aim is to interfere with parasite development and identify new classes of therapeutics to combat parasitic diseases and offset the ever-increasing threat of drug resistance.
Associate Professor in Parasitology
Wellcome Trust Career Development Fellow, Imperial College
Post-doc, Harvard Medical School/Whitehead Institute
PhD, LSH&TM
MPH, Yale School of Medicine
BA,Yale University
You can find a complete list of publication on pubmed.
The lab is located in the Molteno Building on the University Downing Site.
Our address is:
Artavanis-Tsakonas Lab
Department of Pathology
University of Cambridge
Tennis Court Road
Cambridge CB2 1QP
You can get in touch with Katerina on ka447@cam.ac.uk or 01223764505